The difference in game dev for love or money

first_imgThe difference in game dev for love or moneyEarth Analog developer Roy van Ophuizen has found more success making games since he stopped doing it for a livingBrendan SinclairManaging EditorWednesday 24th March 2021Share this article Recommend Tweet ShareLast month, Roy van Ophuizen released the space exploration game Earth Analog on Steam.And while the genre seems to be trending up with some notable acclaimed entries in recent years, it’s not difficult to see what makes Earth Analog a little different.In Earth Analog, players flying through space have a device that can bend space-time, changing the planetary environments in real-time in ways that have an assortment of implications for the gameplay.”It has an aesthetically pleasing effect, but it’s also a means to unlock pathways within the game, so it also has a gameplay effect,” Van Ophuizen tells GamesIndustry.biz. “And you have to take care, because if the environment changes, you have to take care not to crash or something.”Van Ophuizen explains that the seed for Earth Analog was planted in 2015 when he learned about an image rendering technique called ray marching.”It’s basically a form of ray tracing,” he explains. “But you don’t need ray tracing hardware for it. It allows you to visualize complex mathematical functions. For instance, these fractals, strange repeating patterns.”Van Ophuizen acknowledges the technique still requires a powerful GPU, and that it’s not entirely brand new to the world of games.”It’s often used for things like clouds in other games,” he says. “Whenever something volumetric needs to be visualized, it’s often done with ray marching. It’s difficult to use in other games because the way the world is created doesn’t work with polygon meshes, which are basically the fabric of most games.”The only polygons in Earth Analog are the graphics for the player’s cockpit. Beyond that, the game is one prolonged experiment with ray marching, testing out gameplay that wouldn’t be practical using more conventional rendering techniques.”The technology allows for dynamic terrain,” he says. “It’s pretty easy to change. Because these fractals are formulas, you can just change the parameters and the whole environment changes dynamically. That’s something more often in games is not possible because they use all kinds of optimization structures that rely on the environment to be static.”Earth Analog produces some appropriately otherworldly worldsIt’s been said that shipping any game is a small miracle, perhaps doubly so for Earth Analog considering it’s a mostly solo effort from a developer who gave up on game development as a career more than a decade ago.In 2007, Van Ophuizen started Funcraft Games with an eye toward developing casual games for the masses. He worked on Ballhalla, a puzzle game that caught the attention (and publishing support) of Sandlot Games.And while Ballhalla would not have appeared out of place grouped alongside successful casual titles of the time, it arrived on the cusp of the iPhone era but before the App Store launched.”I think we were too late for the PC casual market,” Van Ophuizen says. “Maybe a year too late. And we were too early for the mobile casual market.”By the end of 2008, he had left the games industry for a software engineering job and put game development behind him because it just “wasn’t lucrative enough to sustain the business.” The new job was better at paying the bills but still stressful, and as the years went by, Van Ophuizen says he found himself needing a creative outlet and a way to relax.”In 2015, I picked it up again more like a pastime activity,” he says. “I make games in my [free time] next to my job. So I have a full-time job and in the evenings I create these games.”While he had the idea for Earth Analog fairly early in his return to game development, it wasn’t his first project back. He returned to development with a couple iOS games before moving to Steam with the sandbox physics game Stacks TNT and the procedurally generated bullet train game Hypertrain.All in all, game development as a hobby has suited Van Ophuizen.”It’s much more comfortable right now since I don’t depend on the income,” he says. “That really makes a difference. It allows me to experiment more, to try different things, go for new ideas and build what I like to build. There’s no stress in creating the game anymore, and I think that benefits the games.”While plenty of developers in a similar situation have run into work-life balance issues by putting game dev on top of their day jobs, Van Ophuizen says he’s not one of them.”Developing games gives me energy,” he says. “It doesn’t cost me anything. It allows me to balance life better because I have a creative outlet and I have something to do in the evenings. It enriches my life.”Van Ophuizen mostly works alone, contracting and collaborating in parts to help round out development. But he also self-publishes, handling all of the marketing and community management chores for his games on his own. “It can be a bit stressful, especially the days after the launch,” he says. “You have to be prepared for a lot of feedback. You have to be present, to show yourself on the forums, and to take people’s feedback seriously… You have to get through it and handle each problem one at a time, you have to release patches, and be present with some Twittering.”Again, while some devs may find that process distasteful, Van Ophuizen says he finds it rewarding. In fact, we only found one aspect of making and selling games Van Ophuizen seemed to show any aversion to. While he would love to see Earth Analog ported to next-gen platforms, that’s a task he admitted he’d probably let some other company handle for him.Related Jobs3D Artist – Mobile Studio – Midlands UK & Europe Big PlanetProducer Indie Game Studio France UK & Europe Big PlanetSenior C++ Unreal Programmer – PC and Console Studio – Austria South East Big PlanetDiscover more jobs in games So if he’s primarily making games for the creative outlet and relaxation and he gets through the development process itself, how does he judge the success or failure of Earth Analog’s public release?”That’s a difficult question to answer,” he says. “In terms of financial success, the game didn’t cost a lot of money to create because most of it I just made myself, basically. I had to license some stuff but it doesn’t involve large chunks of money. There’s financial success because I already earned a lot more than I would have expected.”But more important is just that people enjoyed playing the game. And what I really like is when somebody takes the time to play the game — ten hours or something — and then gives a positive review, that’s the most satisfying part.”Celebrating employer excellence in the video games industry8th July 2021Submit your company Sign up for The Daily Update and get the best of GamesIndustry.biz in your inbox. Enter your email addressMore storiesDeveloper wins against Grand Theft Auto DMCA takedownTake-Two loses claim to reversed-engineered source made by fansBy Danielle Partis 2 hours agoFirst-party Ubisoft titles will now be branded as ”Ubisoft Originals”Change was made alongside the announcement of new Tom Clancy titleBy Danielle Partis 23 hours agoLatest comments Sign in to contributeEmail addressPasswordSign in Need an account? Register now.last_img read more

Kong Sun to boost Chinese DG PV by 600 MW

first_imgKong Sun to boost Chinese DG PV by 600 MWThe Hong Kong-based investment company is to collaborate with Chinese EPC Wuxi Liansheng on the development of the distributed solar projects. December 4, 2014 Ian Clover Installations Legal Manufacturing Markets Markets & Policy Share Hong Kong investment company Kong Sun Holdings Limited has announced this week a partnership that will swell China’s growing distributed generation (DG) solar capacity by 600 MW over the next three years. Kong Sun will partner with Chinese EPC firm Wuxi Liansheng to develop DG systems across China in a collaborative project due to commence in 2015. The framework agreement announced by Kong Sun gives the company priority rights to invest in any DG project developed by Wuxi Liansheng that has a capacity greater than 5 MW. The investment company added that the expected internal rate of return (IRR) is higher than 12% per project. Kong Sun’s movement into China’s growing DG sector could be a sign that the larger investment firms are beginning to support this growing segment of the market. Having previously operated solely within the ground-mount, utility-scale PV sector, this cooperation with Wuxi Liansheng, plus an earlier agreement announced late last month with Yucheng Hangyu, signifies a “furtherance of the Group’s entrance into the DG PV power system market”, read a company statement. Kong Sun, formerly a large player in China’s real estate market, switched its attentions to solar PV in the Fall of this year, quickly stockpiling a solar portfolio of 70 MW. The company’s pledge to help develop China’s DG industry will be welcomed within the People’s Republic. Bold plans announced earlier this year to source 8 GW of a targeted annual growth capacity of 14 GW from DG have thus far fallen short. In May, data from China’s National Energy Agency (NEA) revealed that just 188 MW of DG capacity had been installed, and despite hopes being pinned on an end-of-year glut boosting numbers, solar analysts have warned that further contractions are likely at the end of the year – a situation that could allow Japan to end 2014 as the world’s largest market in terms of new PV capacity added.Popular content The Hydrogen Stream: 20 MW green hydrogen plant in Finland, two Australian projects move forward Sergio Matalucci 20 April 2021 pv-magazine.com Storegga, Shell and Harbour Energy want to set up a 20 MW blue hydrogen production facility in the U.K. Australia’s Origin Energy wants to build a hy… Enabling aluminum in batteries Mark Hutchins 27 April 2021 pv-magazine.com Scientists in South Korea and the UK demonstrated a new cathode material for an aluminum-ion battery, which achieved impressive results in both speci… ITRPV: Large formats are here to stay Mark Hutchins 29 April 2021 pv-magazine.com The 2021 edition of the International Technology Roadmap for Photovoltaics (ITRPV) was published today by German engineering association VDMA. 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Yet sometimes, even when best practice is applied – and without particul… The Hydrogen Stream: 20 MW green hydrogen plant in Finland, two Australian projects move forward Sergio Matalucci 20 April 2021 pv-magazine.com Storegga, Shell and Harbour Energy want to set up a 20 MW blue hydrogen production facility in the U.K. Australia’s Origin Energy wants to build a hy… Enabling aluminum in batteries Mark Hutchins 27 April 2021 pv-magazine.com Scientists in South Korea and the UK demonstrated a new cathode material for an aluminum-ion battery, which achieved impressive results in both speci… ITRPV: Large formats are here to stay Mark Hutchins 29 April 2021 pv-magazine.com The 2021 edition of the International Technology Roadmap for Photovoltaics (ITRPV) was published today by German engineering association VDMA. The re… Solar park built on rough wooden structures comes online in France Gwénaëlle Deboutte 26 April 2021 pv-magazine.com French company Céléwatt energized its 250 kW ground-mounted array, built with mounting structures made of raw oak wood.April 26, 2021 Gwénaëlle Debo… Spanish developer plans 1 GW solar plant coupled to 80 MW of storage, 100 MW electrolyzer Pilar Sánchez Molina 22 April 2021 pv-magazine.com Soto Solar has submitted the project proposal to the Ecological Transition and the Demographic Challenge (Miteco). The solar plant could start produc… We all trust the PV performance ratio test Dario Brivio, Partner 20 April 2021 pv-magazine.com The performance ratio test is at the core of the handover from EPC to owner. Yet sometimes, even when best practice is applied – and without particul… The Hydrogen Stream: 20 MW green hydrogen plant in Finland, two Australian projects move forward Sergio Matalucci 20 April 2021 pv-magazine.com Storegga, Shell and Harbour Energy want to set up a 20 MW blue hydrogen production facility in the U.K. Australia’s Origin Energy wants to build a hy… 123456Share Ian Clover Ian joined the pv magazine team in 2013 and specializes in power electronics (inverters) and battery storage. Ian also reports on the UK solar market, having worked as a print and web journalist in Britain for various multimedia companies, covering topics ranging from renewable energy and sustainability to real estate, sport and film.More articles from Ian Clover [email protected] Related content Lack of policy hampers energy storage in Cyprus Ilias Tsagas 29 April 2021 pv-magazine.com Although the government last month started offering purchase incentives for residential batteries, a net metering regime… ITRPV: Large formats are here to stay Mark Hutchins 29 April 2021 pv-magazine.com The 2021 edition of the International Technology Roadmap for Photovoltaics (ITRPV) was published today by German enginee… African solar installers feel the pinch of rising panel prices Max Hall 26 April 2021 pv-magazine.com With Chinese manufacturers having warned they will pass on escalating component costs, and shipping expenses soaring sin… The weekend read: China’s push for decarbonization Andreas Walstad 24 April 2021 pv-magazine.com The carbon market is finally a reality in China. 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Cracking the case for solid state batteries pv magazine 29 April 2021 pv-magazine-australia.com Scientists in the UK used the latest imaging techniques to visualize and understand the process of dendrite formation an… iAbout these recommendations Leave a Reply Cancel replyPlease be mindful of our community standards.Your email address will not be published. Required fields are marked *CommentName * Email * Website Save my name, email, and website in this browser for the next time I comment. By submitting this form you agree to pv magazine using your data for the purposes of publishing your comment.Your personal data will only be disclosed or otherwise transmitted to third parties for the purposes of spam filtering or if this is necessary for technical maintenance of the website. 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The revival of Indian Economy, The demand and supply side

first_imgShort term and long term reforms to increase the supply- Farmers must be provided loans at low-interest rates or the rates subsidized by the central and the state governments. Proper infrastructure for them to supply their harvests to give farmers an instant relief. Along with these, better MSPs for the farmers will help them sustain this battle in a more significant manner. Manufacturing sectors needs a substantial boost, for the automobiles sector, in order to encourage the producers, relaxes on high taxes will act as a catalyst for an improved supply of motor vehicles. The increase in production will also positively affect the services sector, where a considerable number of layoffs are done recently. Adding to this, the government should make a clear stand on the future of electric vehicles, as the ambiguity is a hurdle in front of the manufacturing companies to reduce the supply. The Demand SidePrivate consumption and investments have taken a sharp dip in the first three quarters of 2020. In order to increase consumption, liquidity in the economy has to be increased. One way to do is giving employment to those who are capable of working but are unemployed. Real estate and construction sector, for instance, employees a vast workforce in the country. Calling it a dead market would not be an overstatement. Although the government decided to infuse in this sector, the process is a slow one; this has to pick up so that a large fraction of the population gets work. More the money more will be the demand and more growth in other sectors of the economy. Another component just like the real estate is the MSMEs. A large chunk of the country’s population is associated with MSMEs. Providing quick and easy loans to this sector will increase liquidity to many folds and hence again increase the demand in the market. The government has merged various banks, but they will be of maximum use when these entities provide loan at a low-interest rate until the economy gets back on track. Petrol is an essential element that impacts the lives of almost everyone, and the prices of petrol and diesel are on the higher side of the curve. The decrease in petroleum prices will encourage people to buy automobiles as both being complementary goods.The festive season is around the corner, and it can bring some relief for the economy if the supply and demand in the country are maintained well. The Supply Side Agriculture, manufacturing and services are the three pillars of any economy. In India’s context, despite the majority of people live in rural areas, agriculture contributes well below 20% to the GDP. Same is the case with manufacturing, that has not much to offer to the economy. The growth of these two sectors has been the lowest lately. The slump in recent times has hit these two sectors even harder. Despite an excellent harvesting season and a lot of harvested crops, farmers in the country do not have access to markets to sell their crops. COVID-19 has further hit the automobiles sector, which was in decline. In India, motor vehicles attract taxes as high as 28% and additional levies up to 22%. These figures are some significant factors for the decline in automobiles sales. The economy of India is in bad shape for the past few years. In 2016, demonetization followed by a raw planned implementation of GST were the starters for the bad phase of the Indian economy. On top of this, there had been an uncountable number of banking and NBFCs crisis. The ongoing Pandemic has further deepened the dip in the economy. Businesses have been shut down; the unemployment rate is at an all-time high; companies have laid off millions of workers because the revenue of the companies has gone down like a rocket. From agriculture to big corporates to micro, small and medium enterprises, a slump is everywhere. Many economists have termed it as the fourth recession in Indian history since independence. Some sustainable measured needed to be taken before things get more complicated than before.So, what are the key areas that should be targeted?Demand and supply are always vital factors that define a company, a market and the economy of a country. For a country of India’s size and population where there are millions of firms to supply for the demands of over a billion people, this concept of demand and supply becomes even more crucial. The role of the government to fluctuate the demand and supply in a country is something that knits it together. Disclaimer: These are my thoughts and not of SME IIT Jodhpur.last_img read more

Lady Devils host three-day Volleyball Camp

first_img Lady Devils host three-day Volleyball CampMay 29, 2018Peoples DefenderSports0 HomeSportsLady Devils host three-day Volleyball Camp PreviousArey’s basketball ‘crusade’ will continue at the collegiate levelNextDistrict final disappointment again for Lady Indians Around the WebThis Video Will Soon Be Banned. Watch Before It’s DeletedSecrets RevealedThis Weird Method Can Restore Your Vision Naturally (Watch)Healthier LivingHave an Enlarged Prostate? Urologist Reveals: Do This Immediately (Watch)Healthier LivingIf You Have Ringing Ears Do This Immediately (Ends Tinnitus)Healthier LivingWomen Only: Stretch This Muscle to Stop Bladder Leakage (Watch)Healthier LivingRemoving Moles & Skin Tags Has Never Been This EasyEssential HealthThe content you see here is paid for by the advertiser or content provider whose link you click on, and is recommended to you by Revcontent. As the leading platform for native advertising and content recommendation, Revcontent uses interest based targeting to select content that we think will be of particular interest to you. We encourage you to view your opt out options in Revcontent’s Privacy PolicyWant your content to appear on sites like this?Increase Your Engagement Now!Want to report this publisher’s content as misinformation?Submit a ReportGot it, thanks!Remove Content Link?Please choose a reason below:Fake NewsMisleadingNot InterestedOffensiveRepetitiveSubmitCancel On May 14, 15, and 16, North Adams High School hosted a youth volleyball camp. The camp was conducted by Coach Katie Ragan, Coach Eric Toole, and the NAHS high school volleyball players (Christin Young, Emma Geeslin, Abbi Stacy, Cortney Brown, Desiree Ison, Skylar Johnson, Sydney Collett, Wylie Shipley, DeLaney Harper, Marah Call, Sierra Kendall, Myla Toole, Samara Myers, Jadyn Wright, Lizzie Gill, Chelsy Conley, and Addisyn Werner).Twenty-one girls currently in grades 4-7 attended the camp. The campers were:: Kensley Mathias, Natalie Ragan, Paige Evans, Halena Colvdill, Danielle Ison, Lillie Singleton, Leah Lamb, Kirsten Campbell, Daisy Holt, Kendall Sullivan, Karah McKinney, Karie Osman, Brea Stout, Karlie Kennedy, Olivia Wright, Ryleigh Collett, Jaylynn Collett, Riley Richey, Liberty Meyer, Reece Meyers, and Keetyn Hupp.   The camp included instruction, fun games, and competitions. Powered By 10 Sec Mama’s Deviled Eggs NextStay Mama’s Deviled EggsNOW PLAYINGBest Carrot Cake EverNOW PLAYINGApple Pie BitesNOW PLAYINGApple Pie Bites With Caramel SauceNOW PLAYINGOld Fashioned Soft and Buttery Yeast RollsNOW PLAYINGHawaiian Roll Ham SlidersNOW PLAYING5 Easy and Delicious Crock Pot Meatball Appetizer RecipesNOW PLAYINGHomemade Caramel SauceNOW PLAYINGCream Cheese Cake Mix CookiesNOW PLAYINGHow to Slice & Mince Vegetables Like a ProNOW PLAYINGPumpkin Cream Cheese BarsNOW PLAYINGHow to Knead DoughNOW PLAYINGHow to Use a Meat ThermometerNOW PLAYINGSlow Cooker/Crock Pot HintsNOW PLAYINGHow to Quarter a ChickenNOW PLAYINGHow to Clean Garbage DisposalsNOW PLAYINGHow to Clean Stainless Steel SinksNOW PLAYINGHow to Cook Scrambled EggsNOW PLAYINGHow to Peel Hard Boiled EggsNOW PLAYINGHow to Chill a Drink in 2 MinutesNOW PLAYINGHow to Chop an Onion PerfectlyNOW PLAYINGPerfect Bacon Every TimeNOW PLAYINGSweet Alabama PecanbreadNOW PLAYINGParmesan Baked Pork ChopsNOW PLAYINGPrime Rib Roast Au Jus Perfect Every Time! No FailNOW PLAYING Arrow Left #1 Icon Created with Sketch. Arrow right #1 Icon Created with Sketch. Top Searches Top Searches AdamsSchoolVommo last_img read more

Police: Bayonne man involved in 2 hit-and-runs after huffing cleaner spray

first_imgBayonneCrime Share on Facebook Tweet on Twitter Bayonne man pepper sprayed, arrested after punching cop in the face, authorities say 2 COMMENTS CarePoint Health reaches deal for Cigna Health Insurance to join their network nj24/7 Bayonne Previous articleWith Drasheff retiring, Guttenberg Councilman Zitt announces mayoral runNext articleAt 1st tax reval info session, Fulop still says Jersey City was chosen selectively John Heinis By John Heinis – March 10, 2017 4:15 pm 2 Danny A Bayonne man was charged with driving under the influence after being involved in two hit-and-runs, admitting to police he inhaled spray from canned electronics cleaner to get high.By John Heinis/Hudson County ViewRobert Long, 45, of Bayonne, was charged with driving under the influence, driving while intoxicated, possession of a syringe, possession of narcotic paraphernalia and possession of toxic chemicals, according to Police Capt. Janine Foy.On Wednesday around 1:29 p.m., Long struck a parked Toyota Camry near the intersection of Avenue F and Mechanic Street, before later hitting the pillar of a building at 471 Broadway, officials said.Long continued driving to the area of 20th Street and Avenue C, where he abandoned his blue Dodge Dakota pickup truck and fled the scene on foot, authorities said.Based on numerous tips from eyewitnesses, Long was apprehended in the area of West 19th Street between John F. Kennedy Boulevard and Avenue C, police said.According to officials, after being found to be in possession of cans of electronics cleaner, he admitted to using the spray cans as an intoxicant. Huff and puff and get…….arrested! RELATED ARTICLESMORE FROM AUTHOR Bayonne Police: Bayonne man involved in 2 hit-and-runs after huffing cleaner spray Facebook Twitter Police: 45-year-old man arrested for attempting to have sex with 15-year-old girl in Secaucus March 14, 2017 2:23 pm at 2:23 pm Crime TAGSbayonne policeduihit-and-run SHARE March 29, 2017 3:31 pm at 3:31 pm This is no Joke, Dan Comments are closed.last_img read more

Woman seeks ‘eternal sleep’ for boyfriend by poisoning him with Drano, police say

first_imgABC News(SALT LAKE CITY) — A Utah woman poisoned her boyfriend with Drano because she wanted him to go into “eternal sleep,” according to police.Elle Weissman, 43, was charged with attempted murder after she allegedly tricked her boyfriend into drinking Drano drain cleaner by telling him that it was his medicine, police said in a statement Thursday.The allegations came to light on Monday when the woman’s 50-year-old boyfriend arrived at an urgent care center in Salt Lake City where he was treated for symptoms related to poisoning.Weissman told medical staff that she had “given her live-in boyfriend Drano so he would go into eternal sleep,” according to the Salt Lake City Police Department.“The girlfriend/suspect, 43 year-old Elle Weissman, told investigators post-Miranda that she had intentionally given her boyfriend Drano knowing that it would kill him,” the department said in a statement. “The suspect said her boyfriend thought she was giving him his medicine.”Weissman was booked into the Salt Lake County Jail for attempted murder and surreptitious administration of a certain substance.She was being held on $100,000 bond as of Friday morning.The victim is still hospitalized.Copyright © 2019, ABC Radio. All rights reserved.last_img read more

Expect The Unexpected: The Best Things I Saw At Escape Music Festival

first_imgPlacebo’s big, North American comeback. No other description needed. Escape promised a party like no other and they certainly delivered through the Ibiza-party inspired Elrow Stage. I have to admit that I am not familiar with many of the DJs that play in the rave tent such as Boris and Miss Kitten, as most have their stronger, core fan bases across the pond in the UK, Spain, and the rest of Europe. Yet the sheer mayhem and spectacle of Escape’s smaller stage was more than enough to break this slightly-stoic music fan. Within minutes, I was dancing in a stream of constant confetti with fellow fans wearing inflatable doughnuts and characters in stilts. Parties like the one I partook in at The Elrow Stage are hard to come by stateside, but it was certainly something not to be missed out on. Yeasayer Was the Wildcard Hit of the Festival Mayer Hawthorne’s smooth and soulful set complete with classy, full band. Although he was 35 minutes late to the stage, he certainly left an impression on everyone there.ASTR’s surprisingly energetic and fantastic main stage show. They’re a fantastic up-and-coming band. As the headliner of the better-attended day of Escape, Moby came prepared with a plan to leave a lasting impression; he intended to make the audience move. His goal was successfully achieved. Not one person was standing still during the highly recognizable producer’s 90-minute DJ set. Moby had a strong command over the crowd with his progressive and ambient grooves, so much so that I didn’t want the party to stop. While he is one of the most recognizable figures in electronic music, Moby does not tour nearly as often as he used to, citing that more time on the road leaves him with less time to create music. It was a rare, fantastic set, one that highlighted the entirety of the festival.Girl Talk Ends Escape On A High Note Gregg Gillis, aka Girl Talk, is one of the first electronic artists of the millennial age to challenge the creative status quo and because of that, he is synonymous with the term “mash-up artist”. Needless to say, when he took the stage as the closing act of Escape Music Festival, the crowd went wild. In fact, the small audience adored him so much that many of them stormed the stage. While the set was only an hour long due to a strict curfew, the DJ made the whole 60 minutes worth it by bringing his A-game to all those still around. After witnessing a slight air of negativity throughout the weekend, Girl Talk’s closing performance made the entire festival worth it. A few more notable moments from the inaugural Escape Music Festival:The Joy Formidable’s set was so intimate that the lead singer was able to come out into the crowd and play an unplugged song with being accosted. Between the hard-hitting Euro DJs on the lineup and the show stopping headliners scheduled for later in the first evening, the Brooklyn-based indie rock band Yeasayer felt somewhat out of place. Once they got started, however, we were blown away by their performance. With a tight and well balanced set combined with a very positive reaction from the crowd, the group managed to rock the main stage and leave a lasting impression. It seemed as if the band and the audience were feeding off of each others’ positive energy. Whatever the factor was, it was a fantastic set that raised the bar for the rest of the weekend’s music.When Moby DJs, You Dance!center_img – Marisa Frydman (@musicalmarisa)[All photos by Corey Regensburger] [STRFKR][Neon Indian] And finally, upbeat and unexpectedly fantastic DJ sets from STRFKR and Neon Indian! As we took the ferry over from the Southern tip of Manhattan to Governor’s Island through the gloomy skies on a seasonable cold first day of Escape Music Festival, we had one distinct thought; this is going to be unlike any other festival we’ve ever attended. Sure enough, we were correct.Escape promoted itself as escape from harsh reality, an Ibiza-style party the likes of something New Yorkers have never witnessed. And because of its last minute venue change from Brooklyn’s Pier 9 to Governor’s Island, which is usually closed in October, the boat ride made the festival feel more like a literal escape from the city. Although the method of travel proved itself to be a nuisance for artists and fans alike, the view from the main stage was simply unbeatable.Logistical errors aside, this small festival packed a powerful punch. While attendance was noticeably low, Escape provided great way for all artists and DJs to connect with their fans on a more intimate level. Most artists were even able to party with their biggest admirers mid-performance! The small audience size lent itself to some amazing, you-had-to-be-there, music moments that could compete against experiences at stadium shows and other larger festivals. There was so much great music from many diverse backgrounds at Escape. Yet the moments touched upon are the ones that impacted everyone in attendance.The Crystal Method Cuts Up A Dreary SaturdayThe Crystal Method was the one of the first full acts at Escape Music Festival. The electronic music duo has been dominating the dance scene since the early 90s.  Scott Kirkland and Ken D Jordan are always a realiable way to get the party started and they delivered to an excited crowd. The Crystal Method were effectively able to cut through the thick grey sky and make the dreary October sky seem like a sunny day in July.The Elrow Stage Is Pure Insanitylast_img read more

Protein folding: Life’s vital origami

first_imgFold a napkin wrong, and you lose points with Miss Manners.Fold a protein wrong, and you could set off a chain of genetic malformations that can lead to disease, or (more happily) to evolutionary change.The way proteins fold, and the good and bad effects of this molecular phenomenon, are what keeps biologist Susan L. Lindquist busy.Lindquist Ph.D. ’76, a Radcliffe Fellow this year, is an award-winning professor and researcher at the Massachusetts Institute of Technology (MIT) and a former director of the Whitehead Institute. She shared her insights on protein folding with an audience of 70 last week (March 5) at the fellowship program’s 34 Concord Ave. headquarters.“Two-thirds of the people in this room think proteins are food,” said Lindquist, leading off her lively one-hour presentation spiced with movie clips, arresting charts, and jokes that even nonbiologists could laugh at. “But we’re mostly made of proteins.”Proteins constitute about 50 percent of the dry weight of animals and bacteria. They transport chemicals in and out of cells, speed up chemical reactions (as enzymes), and comprise the building blocks of cellular structure. They also only work the way they are supposed to when they fold properly, said Lindquist.Folded the right way, proteins “help an organism stay the same,” she said.Protein folding is normally kept in check by “chaperone” systems that clamp proteins in place during cellular transport. Lindquist said that “very specific degradation machinery” helps dispose of nonstandard — “misfolded” — proteins.But sometimes misfolded proteins overwhelm this protective system. To blame are inherited genetic mutations or environmental stressors like heat, oxygen deprivation, and aging.If proteins fold the wrong way, they can lead to disease states — cancer, cystic fibrosis, or neurological disorders like Parkinson’s or Huntington’s disease. Lindquist and her research team (including 2005-06 Radcliffe Fellow Luke Whitesell) are using yeast-based models of protein-folding diseases to develop novel approaches to therapy. (Lindquist is also co-founder of the Cambridge-based FoldRx Pharmaceuticals.)“Misfolding is a big part of diseases,” said Lindquist of the side of her research looking into therapies. “[We] really want to make people who are sick better.”But misfolded proteins can also help organisms evolve — “reach new forms and functions,” as Lindquist put it. Organisms can store protein misfolding variations in a “silent form” until — awakened by environmental stressors — they may prompt evolutionary change.Most evolutionary change is slow, she said. But protein folding — “conformational change” — may be a new frontier in understanding some forms of rapid evolution.Lindquist showed a picture of two different-looking Rocky Mountain monkey flowers, one that has evolved to be pollinated by bumble bees and the other by hummingbirds. Their “massive changes” in appearance and function, she said, were the result of only a handful of major gene changes. (A gene is a unit of DNA that codes for a protein.)But saying that protein misfolding is an agent of change “is by no means completely accepted” among evolutionary biologists, she said of her controversial claim. “This is a work in progress.”As a graduate student in biology at Harvard in the 1970s, Lindquist didn’t mind a little controversy. She was already bucking the system by being where she was — a female in a department where female faculty members were outnumbered by males 65 to two.The disparity, she said in one interview, freed her to take risks. That included changing her laboratory work, before she had tenure, from fruit flies to yeasts.“Yeasts are our best friends,” said Lindquist. After all, they perform the chemistry responsible for making bread, beer, and wine.But in the lab, yeasts are also a handy means of studying protein mutations, and getting at the root of how those mutations contribute to disease.One mechanism Lindquist studies is heat shock proteins (Hsp), which help other proteins fold correctly and which buffer (i.e., hide) small mutations. In yeast, she’s investigating Hsp90. It’s an abundant type of heat shock protein that a normal, self-regulating cell only needs a little of — but which floods to rescue when protein misfolding occurs.Here’s the catch. Hsp90 rescues not only normal proteins, but also the unstable mutant proteins that cause cancer. “The cancer is actively subverting our protective activities,” said Lindquist.But the catch comes with a hope: that scientists can manipulate levels of Hsp90 as a clinical strategy. That takes care. Inhibiting levels of Hsp90 early may be good, said Lindquist; doing it later may unleash mutations.About 20 different clinical trials are currently under way, looking at how to use Hsp90 inhibitors against cancer.While at Radcliffe, Lindquist is one of 13 scientists this year who as fellows are actively pursuing research with Harvard entities. She’s working with the Broad Institute, the Harvard-MIT research collaboration that, along with the Whitehead Institute, investigates the connections between genomics and medicine.“Susan is an extraordinary scientist, teacher, and mentor — all of which are clearly reflected in her presentations,” said Barbara J. Grosz, interim dean of the Radcliffe Institute for Advanced Study. “Her cutting-edge research with Harvard scientists has greatly enriched Radcliffe and Harvard this year.” (In her earlier role as dean of science, Grosz undertook several initiatives to attract leading scientists like Lindquist to Radcliffe.)Lindquist has brought talent and insights to the fellows program, “including her penetrating questions at talks by fellows from all across academic fields and the arts,” said Grosz. “We are delighted to have her with us.”ANIMATED MINI-FEATURE: PROTEINS AT WORKWhy proteins misfold, for good or ill, is explained in part by the environment of the cell itself. Cells are always jam-packed with proteins, and very busy.“It’s not like Fred Astaire and Ginger Rogers,” said Lindquist, who showed a clip of the two graceful dancers gliding around on a big dance floor. “It’s more like a Marx Brothers movie.”Remember the crowded stateroom scene in “A Night at the Opera?” Lindquist showed that as an example of how crowded cells are. And crowded cells are an environment that makes protein misfolding more likely.Lindquist showed another video clip, a Harvard product called “The Inner Life of the Cell,” an animated rendering of a cell’s inner landscape. The cell’s protein workforce has been trimmed by 90 percent, said Lindquist, to allow enough room to show a little of what happens.You’ll see an aquarium-like hive of rolling leukocytes and lily-pad lipid rafts. Motor proteins cakewalk along wavering microtubules. Restless mitochondria bulge like fat worms just beneath the surface of glistening membranes.You won’t see this astonishing film at your local multiplex, but you will find all eight minutes of it, with narration, at the web site of Harvard’s Department of Molecular and Cellular Biology (http://multimedia.mcb.harvard.edu/media.html)[email protected]last_img read more

Trey Anastasio Treats Fans To Intimate Performance At L.A.’s Grammy Museum Following ‘Between My & My Mind’ Screening

first_imgOn Wednesday, the Grammy Museum hosted a special screening of Trey Anastasio‘s Between Me & My Mind documentary in Los Angeles, CA. Following the screening, Trey sat with moderator Scott Goldman to discuss the film and performed an intimate nine-song solo acoustic set.Trey Anastasio opened up the musical portion of the evening with “Snowflakes in the Sand”, a tune Trey debuted in 1999 and recently revived at a solo acoustic performance at Boulder, CO’s Macky Auditorium in December 2018. Trey continued on with “Brian and Robert”, “Blaze On”, “Strange Design”, and Ghosts of the Forest‘s “Brief Time”. “Brief Time” segued into “Free”, which was followed up by “Limb By Limb” and the acoustic debut of “A Life Beyond The Dream”. Trey closed out the performance with “More”, reminding the Southern California crowd to continue vibrating with love and light.In addition to the music, Trey treated attendees to a comical story about Phish‘s tune “Free” and answered fans’ questions including what the original intention was behind the band taking “Ruby Waves” past the 38-minute mark on night three at East Troy, WI’s Alpine Valley Music Theatre.Trey Anastasio discusses “Free”[Video: Andy Magnes]Between Me & My Mind was directed by Jamie Schutz and Steven Cantor, and produced by Schutz. A Phish fan since 1992, Schutz started trading tapes and dreaming of a career in film. Now, 24 years later, Between Me & My Mind marks his feature directorial debut. Canton, a veteran filmmaker and fellow music lover, has directed a plethora of critically acclaimed documentaries including Dancer, Willie Nelson: Still Is Still Moving, the Oscar-nominated Blood Ties: The Life & Work Of Sally Mann, the ESPN 30 For 30 Chasing Tyson and many more.Next up for Trey is an appearance on Live From Here With Chris Thile at New York City’s Town Hall on Saturday, October 12th. For a full list of his upcoming tour dates, ticketing, and more information, head to Trey Anastasio’s website.Setlist: Trey Anastasio | Grammy Museum | Los Angeles, CA | 9/25/2019Set: Snowflakes in the Sand [1], Brian and Robert[1], Blaze On[1], Strange Design[1], Brief Time[1] > Free[1], Limb By Limb[1], A Life Beyond The Dream [2], More[1][1] Trey solo acoustic.[2] Trey solo acoustic; first acoustic performance.last_img read more

Dolly Parton, Jason Isbell & Amanda Shires, Brittany Howard, More Perform On Cyndi Lauper Stream [Watch]

first_imgCyndi Lauper‘s annual Home For The Holidays took place over the weekend, streaming on TikTok Friday and YouTube and Facebook on Sunday. Though the yearly benefit for Lauper’s True Colors United LGBTQ+ non-profit looked a bit different this year as it went digital, it still brought together some big names including Brittany Howard, Jason Isbell & Amanda Shires, Dolly Parton, Phoebe Bridgers, Brandi Carlile, and many more.The full lineup for the event included Adam Lambert, Bette Midler, Billie Eilish, Billy Porter, Billy Steinberg, Boy George, Carson Kressley, Cher, Harvey Fierstein, Henry Rollins, Jackson Browne, Judy Gold, Justin Tranter, Kim Petras, King Princess, LL Cool J, Meg Myers, Sharon Osbourne, Shea Diamond, Taylor Swift, Tom Kelly, Tracy Young, Whoopi Goldberg, and Youth Pride Chorus as well as the cast of Lauper and Fierstein‘s award-winning musical, Kinky Boots.Related: Jason Isbell & Amanda Shires, Ben Gibbard, Fred Armisen, More Perform At SMooCH Benefit [Watch]The 90-minute livestream was filled with memorable moments throughout, but some performances from familiar faces stuck out as highlights. Lauper opened the stream with her Christmas song, “Home For The Holidays” which started things off in a festive mood. Soon after (at 24:56) Bridgers appeared alongside drummer and collaborator Marshall Vore to cover McCartney Trenching‘s “Christmas Song”. The track, which Bridgers released in 2018 as her annual Christmas cover fundraiser, put a more somber spin on the season of giving.Jackson Browne (29:41) slowed things down a bit with “Late For The Sky” in his second appearance at Home For The Holidays, immediately followed by Billy Porter (34:57) who ramped the energy back up with a lively take on Buffalo Springfield‘s “For What It’s Worth”. A little further down the road, national treasure Dolly Parton (45:42) brought back the Christmas spirit with her recent holiday single “Christmas Is”, setting the stage for Brandi Carlile’s (48:10) fitting rendition of “Somewhere Over The Rainbow”.Things kept rolling as Jason Isbell & Amanda Shires (1:11:21) teamed up to perform “The Problem“, the song they released for National Safe Abortion Day back in September. Brittany Howard (1:15:51) provided some late-show energy with a performance of “Georgia” alongside a full band, followed by an unexpected-but-welcome cover of Marc Cohn‘s “Walking In Memphis” from Cher (1:24:54). Lauper (1:30:30) then brought the show to a close with an inspiring performance of her song “True Colors”, for which her charity is named.Watch Cyndi Lauper’s entire Home For The Holidays livestream fundraiser for True Colors United below.Cyndi Lauper & Friends: Home for the Holidays[Video: Cyndi Lauper][H/T Brooklyn Vegan]last_img read more